Saccharomyces boulardii demonstrates multiple health benefits against Candida albicans, a common fungal pathogen linked to gut and systemic infections. Research shows it significantly inhibits C. albicans by targeting key virulence factors:

• Reduces adhesion and biofilm formation: S. boulardii suppresses the ability of C. albicans to adhere to intestinal cells and form biofilms—structures that protect fungi from immune responses and antifungal drugs. Studies using human intestinal cell lines (Caco-2 and Intestin 407) confirm that both S. boulardii and its culture extract significantly reduce adhesion and lower proinflammatory cytokine expression (e.g., IL-8).

• Inhibits filamentation: A major virulence trait of C. albicans is its ability to switch from yeast to invasive filamentous forms. Capric acid, a compound secreted by S. boulardii, is a key agent that inhibits this morphological transition, reducing tissue invasion and damage.

• Disrupts virulence gene expression: Treatment with S. boulardii or its secreted compounds leads to reduced expression of genes like HWP1, INO1, and CSH1, which are essential for adhesion, biofilm formation, and pathogenicity

• Enhances antifungal efficacy: In combination with fluconazole (FLC), capric acid from S. boulardii reduces drug efflux by the Cdr1p transporter, potentially improving the effectiveness of conventional antifungals. However, capric acid alone may increase resistance to amphotericin B (AMB), so combination therapy requires caution.

• Protects against systemic spread: In animal models, S. boulardii reduces translocation of C. albicans from the gut to organs like the liver and kidneys, particularly in immunocompromised hosts. 

FloraMyces™ is the non-pathogenic yeast, Saccharomyces boulardii, which possesses probiotic activity that supports gastrointestinal health and immune function.* This formula contains 500 mg or 10 billion viable cells at the ,time of manufacture of S. boulardii per serving. This strain does not require refrigeration and has the ability to survive passage through the harsh gastric environment, withstanding high acidity, bile and heat.

Benefits of S. boulardii may include increased protection of the digestive mucosa and production of secretory IgA. Also, this strain has been the most studied as a general supplement for optimum gastrointestinal health.*

Made with non-GMO ingredients.

Suggested Use:
As a dietary supplement, take two capsules per day, or as directed by your health care practitioner.

Serving Size: Two Capsules

Amount Per Serving
Saccharomyces boulardii ... 500mg

Other Ingredients: Cellulose (capsule), microcrystalline cellulose, vegetable stearate.

This product does not contain gluten.

10 billion viable cells per serving at time of manufacture.

NOTICE
Color, size or shape may appear different between lots.

Store at room temperature. No refrigeration necessary. Keep out of reach of children.

Disclaimer:

††An IPSOS 2023 survey among US functional medicine practitioners, in an average month, Designs for Health is their personally most trusted practitioner supplement brand, meaning a brand that is sold by healthcare practitioners in their office.

††An Ipsos 2023 study among a random sample of 160 functional medicine practitioners including Doctor's of Osteopathic Medicine, Pharmacists, Acupuncturists, Athletic Trainers, Personal Trainers, Fitness Trainer/Coaches, Chiropractors, Integrative Medicine Specialists, Naturopathic Doctor, Homeopaths, Medical Doctors, Physical Therapists, Nurse Practitioner/Physician Assistants, Registered Nurses, Nutritionists, Massage Therapists, Occupational Therapists and Dieticians that are aware of Designs for Health and recommend supplements to their patients.